The Manila Palm is typically found growing on lime hills, but can also thrive in sandy coastal soils where it demonstrates moderate tolerance to salt. The pistil tip of the palm produces nectar, attracting insects to frequent its flowers. In urban areas, the fruits of the Manila Palm are consumed by the plantain squirrel Callosciurus notatus. Propagation of the Manila Palm is achieved through seed planting, although it is important to note that the germination rate is significantly decreased when the seeds are dried to 80% or 70% of their initial moisture content.

Adonidia merrillii is highly vulnerable to the deadly lethal yellowing disease caused by a bacterial parasite in the phloem, which is spread by the plant-hopper Haplaxius crudus. This bacterial infection appears to spread more rapidly in locations with meticulous horticultural upkeep compared to sandy beach environments, likely because the absence of grass eliminates a preferred host material for the nymphs of Haplaxius crudus. While the palm is a minor host, the coconut tree is the predominant one affected by this disease.

Adonidia merrillii (Arecaceae)